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Bio-identical is the name given to hormones that have the exact same molecular structure as the hormones naturally produced by the human body. A hormone exerts its effect on a cell receptor in the same fashion that a key would insert into a lock. Any deviation from the molecular structure of the hormone will cause problems when it tries to fit into the receptor. Synthetic hormones are similar, but not identical. Since patents are not permitted for natural substances, some pharmaceutical companies made small changes to the hormone structure so that the differences qualified for a patent.
Synthetic hormones are prescribed in traditional hormone replacement therapy (HRT). The problem with synthetic hormones is that although they are able to squeeze into the hormone receptor, the message they send to the cell is different than a natural hormone. This means that the body functions controlled by the hormone are either not functioning as intended or in some cases, not functioning at all. Synthetic hormones have also been linked to unintentional side effects, since they are not identical to the naturally occurring hormones in the human body.
Bio-identical hormones are synthesized in a laboratory and this fact may cause some confusion. In the laboratory, sterols from plants such as soy and wild yam are used to create bio-identical hormones. Other natural materials can be used to achieve the same natural hormones, but these plant sterols are the easiest to transform into human hormones. The starting material is less important. The fact that hormones produced in this way are identical to natural human hormones is what produces the beneficial effects.
In the field of Integrative Medicine, physicians prefer bio-identical hormones whenever hormones are prescribed. Practitioners devote serious thought into the best method to deliver each hormone carefully considering safety, effectiveness and potential side effects. In general, transdermal delivery (cream applied to the skin) is preferred, as this method will bypass the liver and avoid potential conversion into unwanted metabolites. In some circumstances oral or injectable forms are preferred.
The types, combinations and dosages of bio-identical hormones are customized to fit each individual patient and will be discussed in the course of your treatment. The most common hormones prescribed are Estrogen, Progesterone, Testosterone and DHEA. The majority of bio-identical hormone prescriptions will need to be prepared by a compounding pharmacy in their own labs. These pharmacies adhere to strict regulations and certifications to ensure accuracy and quality when preparing the medicine as prescribed by the physician.
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